A Systematic Approach for Establishing Humane Endpoints

Studying humane endpoints in a rat model of mammary carcinogenesis

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

Pain management and humane endpoints.

Humane endpoints for infectious disease animal models.

Since the work of pioneers such as Jenner and Pasteur (Fenner et al. 1997) more than a century ago, animal models have provided essential information in the study of infectious diseases. Although much experimentation can now be accomplished with in vitro systems, animals continue to be necessary for this field for studying the process of inflammation, specific infectious diseases, and pharmacol...

Humane endpoints in the efficacy testing of swine erysipelas vaccines.

For licensing the efficacy of vaccines for veterinary use has to be demonstrated by well-controlled laboratory experiments in which vaccinated and untreated animals of the target species are challenged. Erysipelas challenge tests cause extreme suffering of the unprotected animals with high fever, apathy, large skin lesions, and even death. This paper describes a standardised procedure for the v...

a new approach to credibility premium for zero-inflated poisson models for panel data

هدف اصلی از این تحقیق به دست آوردن و مقایسه حق بیمه باورمندی در مدل های شمارشی گزارش نشده برای داده های طولی می باشد. در این تحقیق حق بیمه های پبش گویی بر اساس توابع ضرر مربع خطا و نمایی محاسبه شده و با هم مقایسه می شود. تمایل به گرفتن پاداش و جایزه یکی از دلایل مهم برای گزارش ندادن تصادفات می باشد و افراد برای استفاده از تخفیف اغلب از گزارش تصادفات با هزینه پائین خودداری می کنند، در این تحقیق ...